Semi-parametric empirical Bayes factor for genome-wide association studies
نویسندگان
چکیده
منابع مشابه
Two semi parametric empirical Bayes estimators
Parametric empirical Bayes PEB may perform poorly when the assumed prior distribution is seriously invalid Nonparametric empirical Bayes NEB is more robust since it imposes no restric tion on the prior But compared with the PEB the NEB may be ine cient for small to medium samples due to the large variation and under dispersion of the NPMLE of the prior Using Monte Carlo simulations we compare t...
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Progress in probabilistic generative models has accelerated, developing richer models with neural architectures, implicit densities, and with scalable algorithms for their Bayesian inference. However, there has been limited progress in models that capture causal relationships, for example, how individual genetic factors cause major human diseases. In this work, we focus on two challenges in par...
متن کاملGenome-wide Association Studies
Progress in probabilistic generative models has accelerated, developing richer models with neural architectures, implicit densities, and with scalable algorithms for their Bayesian inference. However, there has been limited progress in models that capture causal relationships, for example, how individual genetic factors cause major human diseases. In this work, we focus on two challenges in par...
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ژورنال
عنوان ژورنال: European Journal of Human Genetics
سال: 2021
ISSN: 1018-4813,1476-5438
DOI: 10.1038/s41431-020-00800-x